Human GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	GRIA2
Gene ID:	2891
Uniprot ID:	GRIA2_HUMAN
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation. Ubiquitinated by RNF167, leading to its degradation.
Function	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system. It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Protein Name	Glutamate Receptor 2 Glur-2 Ampa-Selective Glutamate Receptor 2 Glur-B Glur-K2 Glutamate Receptor Ionotropic - Ampa 2 Glua2
Database Links	Reactome: R-HSA-399710 Reactome: R-HSA-416993 Reactome: R-HSA-438066 Reactome: R-HSA-9022699 Reactome: R-HSA-9620244
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Endoplasmic Reticulum Membrane Postsynaptic Cell Membrane Postsynaptic Density Membrane Interaction With Cacng2 Cnih2 And Cnih3 Promotes Cell Surface Expression Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Alternative ELISA Names	Glutamate Receptor 2 ELISA kit Glur-2 ELISA kit Ampa-Selective Glutamate Receptor 2 ELISA kit Glur-B ELISA kit Glur-K2 ELISA kit Glutamate Receptor Ionotropic - Ampa 2 ELISA kit Glua2 ELISA kit GRIA2 ELISA kit GLUR2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance