Human Superoxide Dismutase 3 (SOD3) activation kit by CRISPRa
Référence GA104559
Conditionnement : 1kit
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| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | SOD3 |
| Locus ID | 6649 |
| Components | GA104559G1, Superoxide Dismutase 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104559G2, Superoxide Dismutase 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104559G3, Superoxide Dismutase 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| OTI Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003102 |
| UniProt ID | P08294 |
| Synonyms | EC-SOD |
| Summary | This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN404156 | SOD3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
Citations
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