KNG1 antibody
Référence OAGA00072
Conditionnement : 100ul
Marque : Aviva Systems Biology
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for anti-KNG1 antibody - OAGA00072 |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid. 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7) with 0.01% Thimerosal was added as a preservative |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Application | ICC, IF, IHC-P, WB |
| Additional Information | Positive Controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji |
| Reconstitution and Storage | Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human HMW Kininogen. The exact sequence is proprietary. |
| Purification | Purified by antigen-affinity chromatography. |
| Concentration | 1 mg/ml |
| Application Info | WB: 1:500-1:3000 ICC: 1:100-1:1000 IF: 1:100-1:1000 IHC-P: 1:100-1:1000 Optimal dilutions should be determined by the end user. |
| Gene Symbol | KNG1 |
|---|---|
| Gene Full Name | Kininogen-1 |
| Alias Symbols | BK, BDK, KNG, HMWK |
| NCBI Gene Id | 3827 |
| Protein Name | Kininogen-1 |
| Description of Target | High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond. |
| Uniprot ID | P01042 |
| Protein Accession # | NP_000884.1 |
| Molecular Weight | 72 kDa |
-
What is the species homology for "KNG1 Antibody (OAGA00072)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
-
How long will it take to receive "KNG1 Antibody (OAGA00072)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
-
What buffer format is "KNG1 Antibody (OAGA00072)" provided in?
This item is provided in "Liquid. 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7) with 0.01% Thimerosal was added as a preservative".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "KNG1 Antibody (OAGA00072)"?
This target may also be called "BK, BDK, KNG, HMWK" in publications.
-
What is the shipping cost for "KNG1 Antibody (OAGA00072)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
-
What is the guarantee for "KNG1 Antibody (OAGA00072)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "KNG1 Antibody (OAGA00072)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "72 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "KNG1 Antibody (OAGA00072)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "KNG1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "KNG1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "KNG1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "KNG1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "KNG1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "KNG1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.