Our MDM2/Control 12 FISH probe is designed to detect MDM2 amplifications and deletions. The probe comes labeled in orange and green, but can be customized to meet your needs.  

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Gene Summary

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Gene Details

Gene Symbol: MDM2

Gene Name: MDM2 Proto-oncogene

Chromosome: CHR12: 69201970-69239212

Locus: 12q15

References

Customer Publications

There are currently no FISH related publications for this gene.