MFN2 Antibody - N-terminal region
Référence ARP42419_P050-25UL
Conditionnement : 25ul
Marque : Aviva Systems Biology
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MFN2 Antibody - N-terminal region (ARP42419_P050)
| Datasheets/Manuals | Printable datasheet for anti-MFN2 (ARP42419_P050) antibody |
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| Tested Species Reactivity | Human, Mouse |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human MFN2 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 82% |
| Peptide Sequence | Synthetic peptide located within the following region: STVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEAFLLTEGSEEKRSAKT |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-MFN2 (ARP42419_P050) antibody is Catalog # AAP42419 (Previous Catalog # AAPP24764) |
| Reference | Chung,K.W., (2008) Neurology 70 (21), 2010-2011 |
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| Gene Symbol | MFN2 |
| Gene Full Name | Mitofusin 2 |
| Alias Symbols | HSG, MARF, CMT2A, CPRP1, CMT2A2, HMSN6A, CMT2A2A, CMT2A2B |
| NCBI Gene Id | 9927 |
| Protein Name | Mitofusin-2 |
| Description of Target | MFN2 is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. It is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. |
| Uniprot ID | O95140 |
| Protein Accession # | NP_055689 |
| Nucleotide Accession # | NM_014874 |
| Protein Size (# AA) | 757 |
| Molecular Weight | 86kDa |
| Protein Interactions | UBC; MARCH5; PARK2; UBE2N; MFN2; TER94; MAVS; vpr; HUWE1; MAPK9; |
