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Mifepristone (RU486) [84371-65-3]
Référence 10-1053-100mg
Conditionnement : 100mg
Marque : Focus Biomolecules
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Mifepristone | Glucocorticoid antagonist
CAS:
84371-65-3
Catalog Number:
10-1053
Activity:
Glucocorticoid antagonist
Alternate Names:
RU486
Chemical Name:
11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Molecular Weight:
429.59
Molecular Formula:
C29H35NO2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Mifepristone (84371-65-3) is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3.
References/Citations:
1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses; Annu. Rev. Med. 48 129
2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins; J. Steroid Biochem. 31 161
3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor; Exp. Cell Res. 147 177
CAS:
84371-65-3
Catalog Number:
10-1053
Activity:
Glucocorticoid antagonist
Alternate Names:
RU486
Chemical Name:
11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Molecular Weight:
429.59
Molecular Formula:
C29H35NO2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee
Mifepristone (84371-65-3) is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3.
References/Citations:
1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses; Annu. Rev. Med. 48 129
2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins; J. Steroid Biochem. 31 161
3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor; Exp. Cell Res. 147 177
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