Mouse HDAC6 (Histone Deacetylase 6) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Hdac6
Gene ID:	15185
Uniprot ID:	HDAC6_MOUSE
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level).
Post Translational Modifications	Phosphorylated by AURKA.phosphorylation increases HDAC6-mediated deacetylation of alpha-tubulin and subsequent disassembly of cilia. Ubiquitinated. Its polyubiquitination however does not lead to its degradation. Sumoylated in vitro.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly.via deacetylation of alpha-tubulin. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
Protein Name	Histone Deacetylase 6 Hd6 Histone Deacetylase Mhda2 Tubulin-Lysine Deacetylase Hdac6
Database Links	Reactome: R-MMU-3371511 Reactome: -MMU-350054 Reactome: -MMU-5617833 Reactome: -MMU-9646399
Cellular Localisation	Cytoplasm Cytoskeleton Nucleus Perikaryon Cell Projection Dendrite Axon Cilium Microtubule Organizing Center Centrosome Cilium Basal Body It Is Mainly Cytoplasmic Where It Is Associated With Microtubules
Alternative ELISA Names	Histone Deacetylase 6 ELISA kit Hd6 ELISA kit Histone Deacetylase Mhda2 ELISA kit Tubulin-Lysine Deacetylase Hdac6 ELISA kit Hdac6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance