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Mouse Monoclonal Anti-Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) [Clone ALPP/516]
Référence NB-36-00206-P1ABX
Conditionnement : 100ug
Marque : Neo Biotech
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Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody [ALPP/516]
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SDS-PAGE Analysis of Purified PLAP Mouse Monoclonal Antibody (ALPP/516). Confirmation of Integrity and Purity of Antibody.
Summary
PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo-glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific AP's in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This MAb binds equally well to all common allelic variants (S, F, FS and I) of PLAP and to some variants of AP from normal human testis. This MAb can be used as tracer antibody in ELISA to detect PLAP in serum of S, F, FS and I phenotypes.
Product Properties & Targets
Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Research Areas
Mesenchymal Stem Cell Differentiation, Stem Cell Differentiation
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
ALPP
Positive Control
HepG2 cells. Placenta or seminoma.
Immunogen
Recombinant full-length human ALPP protein
Alternate Names
Alkaline phosphatase, placental type, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, Alkaline phosphatase placental type; Alkaline phosphatase Regan Isozyme; ALP; Alp1; ALPP; Germ-cell alkaline phosphatase; nagao Isozyme; PALP; Placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP-1; PLAP1
Functions
- Alkaline phosphatase that can hydrolyze various phosphate compounds.
Key References
- Millan J.L. et. al., Antigenic determinants of human placental and testicular alkaline phosphatase as mapped by monoclonal antibodies. Eur. J. Biochem. 136: 1-12, (1983).
- Riklund K.E. et. al., Experimental radio-immunotherapy of HeLa tumors in nude mice with 131I-labeled monoclonal antibodies. Anticancer Research, 1990, 10:379-84.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/3042787/
- https://pubmed.ncbi.nlm.nih.gov/3512548/
- https://pubmed.ncbi.nlm.nih.gov/3461452/
- https://pubmed.ncbi.nlm.nih.gov/15815621/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/3001717/
- https://pubmed.ncbi.nlm.nih.gov/6651840/
- https://pubmed.ncbi.nlm.nih.gov/3459156/
- https://pubmed.ncbi.nlm.nih.gov/3422741/
- https://pubmed.ncbi.nlm.nih.gov/2153284/
- https://pubmed.ncbi.nlm.nih.gov/1939159/
- https://pubmed.ncbi.nlm.nih.gov/1730777/
- https://pubmed.ncbi.nlm.nih.gov/11937510/
- https://pubmed.ncbi.nlm.nih.gov/18669648/
- https://pubmed.ncbi.nlm.nih.gov/25775211/
- https://pubmed.ncbi.nlm.nih.gov/11124260/
- https://pubmed.ncbi.nlm.nih.gov/15946677/
- https://pubmed.ncbi.nlm.nih.gov/16815919/
- https://pubmed.ncbi.nlm.nih.gov/20693656/
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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