Mouse Monoclonal Anti-MUC6 (Mucin 6 / Gastric Mucin) [Clone CLH5]
Référence NB-36-00539-P0
Conditionnement : 20ug
Marque : Neo Biotech
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MUC6 (Mucin 6 / Gastric Mucin) Antibody [CLH5]
Formalin-fixed, paraffin-embedded human gastric carcinoma stained with MUC6 Mouse Monoclonal Antibody (CLH5). Courtesy of Dr. Leonor David, IPATIMUP and Medical Faculty, University of Porto, Portugal.
Formalin-fixed, paraffin-embedded human normal stomach. Strong cytoplasmic of glandular cells using MUC6 Mouse Monoclonal Antibody (CLH5). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis of Purified MUC6 Mouse Monoclonal Antibody (CLH5). Confirmation of Integrity and Purity of Antibody
Applications & Dilutions
Summary
The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.
Product Properties & Targets
Functions
- May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/16554811/
- https://pubmed.ncbi.nlm.nih.gov/15081123/
- https://pubmed.ncbi.nlm.nih.gov/7680650/
- https://pubmed.ncbi.nlm.nih.gov/14702039/
- https://pubmed.ncbi.nlm.nih.gov/9195947/
- https://pubmed.ncbi.nlm.nih.gov/9422745/
- https://pubmed.ncbi.nlm.nih.gov/10209489/
- https://pubmed.ncbi.nlm.nih.gov/10330458/
- https://pubmed.ncbi.nlm.nih.gov/11988092/
- https://pubmed.ncbi.nlm.nih.gov/15280409/
- https://pubmed.ncbi.nlm.nih.gov/15979574/
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