Mouse VGLUT1 (Vesicular Glutamate Transporter 1) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Slc17a7
Gene ID:	72961
Uniprot ID:	VGLU1_MOUSE
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in hippocampus (at protein level). Expressed in the molecular layer of the cerebellum and in retina.
Post Translational Modifications
Function	Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake. The vesicular K(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic. Is necessary for synaptic signaling of visual-evoked responses from photoreceptors.
Protein Name	Vesicular Glutamate Transporter 1 Vglut1 Brain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter Solute Carrier Family 17 Member 7
Database Links	Reactome: R-MMU-210500 Reactome: -MMU-428643
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Cell Membrane Multi-Pass Membrane Protein Synapse Synaptosome
Alternative ELISA Names	Vesicular Glutamate Transporter 1 ELISA kit Vglut1 ELISA kit Brain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter ELISA kit Solute Carrier Family 17 Member 7 ELISA kit Slc17a7 ELISA kit Bnpi ELISA kit Vglut1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance