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> N-Acetylcysteine ethyl ester [59587-09-6]

N-Acetylcysteine ethyl ester [59587-09-6]

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Référence 10-5233-10mg

Conditionnement : 10mg

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N-Acetylcysteine ethyl ester | Cell permeable antioxidant

CAS:
 59587-09-6
Catalog Number:
 10-5233
N-Acetylcysteine ethyl ester chemical structure Focus Biomolecules

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10 mg$55.00
50 mg$180.00
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N-Acetylcysteine ethyl ester (59587-09-6) is a lipophilic, cell permeable ethyl ester derivative of N-acetylcysteine.1  In oxidative stressed retinal pigment epithelial (RPE) cells NACET increases viability more efficiently than NAC and pretreatment predisposes RPE cells to oxidative stress resistance.1 Enhances intracellular glutathione concentration in HUVECs.2 Acts as a potent protector against hydroperoxide-induced oxidative damage.3 Protects against UV-induced reactive intermediates in human keratinocytes.4

References/Citations:

  1. Tosi et al. (2021), Superior Properties of N-Acetylcyteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage; Int. J. Mol. Sci. 22 600
  2. Giustarini et al. (2018), N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs; Free Radic. Biol. Med. 126 202
  3. Giustarini et al. (2012), N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential; Biochem. Pharmacol. 84 1522
  4. Steenvoorden et al. (1997), Cysteine derivatives protect against UV-inducede reactive intermediates in human keratinocytes: the role of glutathione synthesis; Photochem. Photobiol. 66 665
CAS:
59587-09-6
Catalog Number:
10-5233
Activity:
Cell permeable antioxidant
Chemical Names:
N-Acetyl-L-cysteine ethyl ester; (R)-Ethyl 2-acetamido-3-mercaptopropanoate
Alternate Name:
NACET; NAC ethyl ester
Molecular Weight:
191.25
Molecular Formula:

C7H13NO3S

Solubility:
Soluble in DMSO (60 mg/ml)
Physical Properties:
White solid
Purity:

>95% by TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

N-Acetylcysteine ethyl ester (59587-09-6) is a lipophilic, cell permeable ethyl ester derivative of N-acetylcysteine.1  In oxidative stressed retinal pigment epithelial (RPE) cells NACET increases viability more efficiently than NAC and pretreatment predisposes RPE cells to oxidative stress resistance.1 Enhances intracellular glutathione concentration in HUVECs.2 Acts as a potent protector against hydroperoxide-induced oxidative damage.3 Protects against UV-induced reactive intermediates in human keratinocytes.4

References/Citations:

  1. Tosi et al. (2021), Superior Properties of N-Acetylcyteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage; Int. J. Mol. Sci. 22 600
  2. Giustarini et al. (2018), N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs; Free Radic. Biol. Med. 126 202
  3. Giustarini et al. (2012), N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential; Biochem. Pharmacol. 84 1522
  4. Steenvoorden et al. (1997), Cysteine derivatives protect against UV-inducede reactive intermediates in human keratinocytes: the role of glutathione synthesis; Photochem. Photobiol. 66 665