Nf2 Mouse Gene Knockout Kit (CRISPR)
Référence KN310926BN
Conditionnement : 1kit
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Nf2 Mouse Gene Knockout Kit (CRISPR)
SKU
KN310926BN
Nf2 - mouse gene knockout kit via CRISPR, HDR mediated
4 Weeks*
| Product Data | |
| Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
|---|---|
| Vector | mBFP-Neo |
| Target Symbol | Nf2 |
| Locus ID | 18016 |
| Components | KN310926G1, Nf2 gRNA vector 1 in pCas-Guide CRISPR vector KN310926G2, Nf2 gRNA vector 2 in pCas-Guide CRISPR vector KN310926BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_001252250, NM_001252251, NM_001252252, NM_001252253, NM_010898, NM_001361675, NM_001361676, NM_001361677 |
| UniProt ID | P46662 |
| Synonyms | merlin |
| Summary | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.[UniProtKB/Swiss-Prot Function] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| GA202869 | Nf2 CRISPRa kit - CRISPR gene activation of mouse neurofibromin 2 | 1 kit | | |
| KN310926 | Nf2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN310926LP | Nf2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN310926RB | Nf2 - mouse gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN510926 | Nf2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.