Octreotide (acetate) [79517-01-4]
Référence HY-17365-50mg
Conditionnement : 50mg
Marque : MedChemExpress
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.
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Octreotide acetate Chemical Structure
CAS No. : 79517-01-4
This product is a controlled substance and not for sale in your territory.
Based on 10 publication(s) in Google Scholar
Other Forms of Octreotide acetate:
- Octreotide In-stock
Description |
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. |
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In Vivo |
Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group. Octreotide-PPSG appears to inhibit the expression of SSTR2 and SSTR5 to a greater extent than that of Octreotide-soln treated group[1]. A test dose of octreotide acetate significantly decreases the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular, q 4 wk) is initiated[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
1079.29 |
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Formule |
C51H70N10O12S2 |
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CAS No. |
79517-01-4 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)(00)[C@H](O)C)=O)C(N[C@H](CO)[C@H](O)C)=O)NC([C@H](N)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N[C@@H]1CC4=CNC5=CC=CC=C45.CC(O)=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
Sealed storage, away from moisture and light
*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light) |
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Solvant et solubilité |
In Vitro:
DMSO : 100 mg/mL (92.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 25 mg/mL (23.16 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 0.9265 mL | 4.6327 mL | 9.2654 mL | 23.1634 mL |
5 mM | 0.1853 mL | 0.9265 mL | 1.8531 mL | 4.6327 mL | |
10 mM | 0.0927 mL | 0.4633 mL | 0.9265 mL | 2.3163 mL | |
15 mM | 0.0618 mL | 0.3088 mL | 0.6177 mL | 1.5442 mL | |
20 mM | 0.0463 mL | 0.2316 mL | 0.4633 mL | 1.1582 mL | |
DMSO | 25 mM | 0.0371 mL | 0.1853 mL | 0.3706 mL | 0.9265 mL |
30 mM | 0.0309 mL | 0.1544 mL | 0.3088 mL | 0.7721 mL | |
40 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5791 mL | |
50 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4633 mL | |
60 mM | 0.0154 mL | 0.0772 mL | 0.1544 mL | 0.3861 mL | |
80 mM | 0.0116 mL | 0.0579 mL | 0.1158 mL | 0.2895 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Octreotide acetate Related Classifications
- GPCR/G Protein Neuronal Signaling
- Somatostatin Receptor