Biological Activity

Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.

Product Citations

• 

  Molecules. 2023 Jan 3;28(1):427.

  A Novel Multi-Target Mu/Delta Opioid Receptor Agonist, HAGD, Produced Potent Peripheral Antinociception with Limited Side Effects in Mice and Minimal
  Probenecid purchased from AbMole

• 

  Peptides. 2023 Mar;161:170943.

  Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain
  Probenecid purchased from AbMole

Chemical Information

Molecular Weight	285.36
Formula	C13H19NO4S
CAS Number	57-66-9
Solubility (25°C)	DMSO 47 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Richard J Everts, et al. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers

[2] Richard J Everts, et al. Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

[3] Ana Laura Coln-Gonzlez, et al. Probenecid: an emerging tool for neuroprotection

[4] Nathan Robbins, et al. The history and future of probenecid

[5] G R Brown. Cephalosporin-probenecid drug interactions