PTEN Polyclonal Antibody, PE-Cy7 Conjugated
Référence bs-0748R-PE-Cy7
Conditionnement : 100ul
Marque : Bioss
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PTEN Polyclonal Antibody, PE-Cy7 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-0748R-PE-Cy7 |
| Product Name | PTEN Polyclonal Antibody, PE-Cy7 Conjugated |
| Applications | WB, FCM |
| Reactivity | Human, Mouse, Rat, Chicken |
| Specifications | |
| Conjugation | PE-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human PTEN |
| Immunogen Range | 101-200/403 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 5728 |
| Swiss Prot | P60484 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | MGC11227; MHAM; MMAC1; Bannayan Zonana; BZS a; Multiple hamartoma (Cowden syndrome); Mutated in Multiple Advanced Cancers 1; Phosphatase and Tensin Homolog; Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN; Phosphatidylinositol 345 trisphosphate 3 phosphatase; Platelet antigen BR; PTEN1; Tensin homolog; TEP1; VLA 2 Receptor Alpha Subunit. |
| Background | Potential tumor suppressor. Acts as a phosphoinositide3-phosphatase by regulating PtdIns (3,4,5)P3 levels. Involved in regulation of the AKT1 signaling pathway. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.The PTEN/MMAC1 discovers the first to have the suppress of the phosphoric acid enzyme activity cancer gene currently.The gene of PTEN locates the chromosome10q23 area, sending forth sex tumor and a few households cancers with the variety to suffer from the comprehensive disease easilyrelevant.The activity that passes to repress the Akt regulates the cell period, the cell ground rule decease and glues to connect.This text discussed PTEN structure, function and its correlationses, the PTEN is in tumor repress function mechanism. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |