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> Puromycin 2HCl [58-58-2]

Puromycin 2HCl [58-58-2]

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Référence 10-2100-50mg

Conditionnement : 50mg

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Puromycin | Translation inhibitor

CAS:
58-58-2
Catalog Number:
10-2100
Activity:
Translation inhibitor
Chemical Name:
(S)-3′-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]-amino]-3′-deoxy-N,N-dimethyl-adenosine dihydrochloride
Molecular Weight:
544.43
Molecular Formula:
C22H29N7O5 2HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
Physical Properties:
Tan solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

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Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

References/Citations:

1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes; Proc. Nat. Acad. Sci. USA, 70 3866
2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation; EMBO J., 26 1385
3) and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction; Biochim. Biophys. Acta, 1150 89

CAS:
58-58-2
Catalog Number:
10-2100
Activity:
Translation inhibitor
Chemical Name:
(S)-3′-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]-amino]-3′-deoxy-N,N-dimethyl-adenosine dihydrochloride
Molecular Weight:
544.43
Molecular Formula:
C22H29N7O5 2HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
Physical Properties:
Tan solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

References/Citations:

1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes; Proc. Nat. Acad. Sci. USA, 70 3866
2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation; EMBO J., 26 1385
3) and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction; Biochim. Biophys. Acta, 1150 89