General Info
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.069ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This ACPP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | Acp3 |
| Gene ID: | 56780 |
| Uniprot ID: | PPAP_RAT |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
Description
| Tissue Specificity | Expressed in prostate epithelium. Also expressed in the pelvic nerve and sacral spinal cord. Localizes in peptidergic and non-peptidergic nociceptive (pain-sensing) neurons. |
| Post Translational Modifications | N-glycosylated. |
| Function | Isoform 1: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons. |
| Protein Name | Prostatic Acid Phosphatase5'-Nucleotidase5'-NtAcid Phosphatase 3Ecto-5'-NucleotidaseFluoride-Resistant Acid PhosphataseFrapProtein Tyrosine Phosphatase Acp3Thiamine MonophosphataseTmpase |
| Database Links | Reactome: R-RNO-6798695 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cell MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneAppears To Shuttle Between The Cell Membrane And Intracellular VesiclesColocalizes With Flot1 At Cell Membrane And In Intracellular VesiclesColocalizes With Lamp2 On The Lysosome Membrane |
| Alternative ELISA Names | Prostatic Acid Phosphatase ELISA kit5'-Nucleotidase ELISA kit5'-Nt ELISA kitAcid Phosphatase 3 ELISA kitEcto-5'-Nucleotidase ELISA kitFluoride-Resistant Acid Phosphatase ELISA kitFrap ELISA kitProtein Tyrosine Phosphatase Acp3 ELISA kitThiamine Monophosphatase ELISA kitTmpase ELISA kitAcp3 ELISA kitAcpp ELISA kit |
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Information sourced from Uniprot.org
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