Rat IREB2 (Iron Responsive Element Binding Protein 2) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Ireb2
Gene ID:	64831
Uniprot ID:	IREB2_RAT
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Ubiquitously expressed in rat tissues, the highest amounts present in skeletal muscle and heart.
Post Translational Modifications	Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.
Function	RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Protein Name	Iron-Responsive Element-Binding Protein 2 Ire-Bp 2 Iron Regulatory Protein 2 Irp2
Database Links	Reactome: R-RNO-917937
Cellular Localisation	Cytoplasm
Alternative ELISA Names	Iron-Responsive Element-Binding Protein 2 ELISA kit Ire-Bp 2 ELISA kit Iron Regulatory Protein 2 ELISA kit Irp2 ELISA kit Ireb2 ELISA kit Irp2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance