Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> SB 202190 [152121-30-7]

SB 202190 [152121-30-7]

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Référence 10-2172-10mg

Conditionnement : 10mg

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SB 202190 | p38 MAP kinase inhibitor

CAS:
152121-30-7
Catalog Number:
10-2172
Activity:
p38 MAP kinase inhibitor
Chemical Name:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Molecular Weight:
331.35
Molecular Formula:
C20H14N3OF
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

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10 mg$30.00
50 mg$110.00
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SB 202190 (152121-30-7) is a potent and selective p38 MAP kinase inhibitor acting at the ATP site.1 Selectively inhibits the p38α and β isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively).2 SB 202190 effectively blocks LPS-induced gene expression in monocytes.3 Induces apoptosis.4 Cell permeable.

References/Citations:

1) Young et al. (1997), Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site; J. Biol. Chem., 272 12116
2) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
3) Manthey et al. (1998), SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRBAs in monocytes; J. Leukoc. Biol., 64 409
4) Nemoto et al. (1998), Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase; J. Biol. Chem., 273 16415

CAS:
152121-30-7
Catalog Number:
10-2172
Activity:
p38 MAP kinase inhibitor
Chemical Name:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Molecular Weight:
331.35
Molecular Formula:
C20H14N3OF
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

SB 202190 (152121-30-7) is a potent and selective p38 MAP kinase inhibitor acting at the ATP site.1 Selectively inhibits the p38α and β isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively).2 SB 202190 effectively blocks LPS-induced gene expression in monocytes.3 Induces apoptosis.4 Cell permeable.

References/Citations:

1) Young et al. (1997), Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site; J. Biol. Chem., 272 12116
2) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
3) Manthey et al. (1998), SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRBAs in monocytes; J. Leukoc. Biol., 64 409
4) Nemoto et al. (1998), Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase; J. Biol. Chem., 273 16415