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> Sodium dodecyl sulfate [151-21-3]

Sodium dodecyl sulfate [151-21-3]

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Sodium dodecyl sulfate is an anionic surfactant commonly used as a detergent, emulsifier, and protein denaturant in various industrial processes, especially in the production of personal care products, cleaners, and laboratory reagents. Sodium dodecyl sulfate has unique chemical properties that make it an effective ingredient in many applications, helping to reduce surface tension and enhance cleaning power.

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Sodium dodecyl sulfate Chemical Structure

Sodium dodecyl sulfate Chemical Structure

CAS No. : 151-21-3

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Other Forms of Sodium dodecyl sulfate:

  • Sodium-dodecyl sulfate-d25 In-stock
Description

Sodium dodecyl sulfate is an anionic surfactant commonly used as a detergent, emulsifier, and protein denaturant in various industrial processes, especially in the production of personal care products, cleaners, and laboratory reagents. Sodium dodecyl sulfate has unique chemical properties that make it an effective ingredient in many applications, helping to reduce surface tension and enhance cleaning power.

In Vitro

Sodium dodecyl sulfate can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium dodecyl sulfate Related Antibodies
Essai clinique
Masse moléculaire

288.38

Formule

C12H25NaO4S
CAS No.

151-21-3
Appearance

Solid

Color

White to off-white

SMILES

O=S(OCCCCCCCCCCCC)(O[Na])=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

H2O : 116.67 mg/mL (404.57 mM; Need ultrasonic)

DMSO : 100 mg/mL (346.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4676 mL 17.3382 mL 34.6765 mL
5 mM 0.6935 mL 3.4676 mL 6.9353 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.67 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.67 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: ≥98.0%

COA (240 KB) HNMR (117 KB)

Instruction de manipulation (2659 KB)
Références

  • [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  • [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.4676 mL 17.3382 mL 34.6765 mL 86.6912 mL
5 mM 0.6935 mL 3.4676 mL 6.9353 mL 17.3382 mL
10 mM 0.3468 mL 1.7338 mL 3.4676 mL 8.6691 mL
15 mM 0.2312 mL 1.1559 mL 2.3118 mL 5.7794 mL
20 mM 0.1734 mL 0.8669 mL 1.7338 mL 4.3346 mL
25 mM 0.1387 mL 0.6935 mL 1.3871 mL 3.4676 mL
30 mM 0.1156 mL 0.5779 mL 1.1559 mL 2.8897 mL
40 mM 0.0867 mL 0.4335 mL 0.8669 mL 2.1673 mL
50 mM 0.0694 mL 0.3468 mL 0.6935 mL 1.7338 mL
60 mM 0.0578 mL 0.2890 mL 0.5779 mL 1.4449 mL
80 mM 0.0433 mL 0.2167 mL 0.4335 mL 1.0836 mL
100 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8669 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium dodecyl sulfate Related Classifications

  • Others
  • Others
  • Biochemical Assay Reagents
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium dodecyl151-21-3Sodium laurylLaurylsulfuric acidBiochemical Assay Reagentspharmaceutical excipientpharmaceutical auxiliariepharmaceutical ingredientsinactive ingredientsstabilitysolubilityprocessabilityabsorptiondistributionmetabolismand elimination (ADME)Inhibitorinhibitorinhibit