TRAIL (TNFSF10) (95-281) Mouse Monoclonal Antibody [Clone ID: 2E5]
Référence SM1847LE
Conditionnement : 100ug
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| Product Data | |
| Clone Name | 2E5 |
|---|---|
| Application | FC, FN |
| Application | Functional application: High neutralizing activity for human TRAIL in biological assays. Flow cytometry: 1-10 μg/ml. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Recombinant soluble fragment (aa 95-281) of human TRAIL |
| Specificity | This antibody reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues. |
| Buffer | Buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Low Endotoxin State: Liquid Ig fraction |
| Concentration | lot specific |
| Purification | Protein A (> 95% pure by SDS-PAGE) |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
| Stability | Shelf life: one year from despatch. |
| Gene Name | tumor necrosis factor superfamily member 10 |
| Database Link | |
| Background | Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2). |
| Synonyms | Apo-2 ligand, TNFSF10, APO2L, Apo-2L |
| Reference Data | |
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