Ulex europaeus (UEA II)

Référence 518886-5mg

Conditionnement : 5mg

Marque : US Biological

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518886 Rabbit Anti-Ulex europaeus (UEA II)

Clone Type
Polyclonal
Grade
Affinity purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Affinity purified Ulex europaeus agglutinin (UEA II) is isolated from gorse seeds and separated from crude extract. This lectin is a glycoprotein that consists of four 24,000 Da monomer subunits that require Ca2+ for binding to its ligands through carbohydrate recognition domain. It is specific for di-N-acetylchitobiose, an oligomer of GlcNAc. The monosaccharide GlcNAc is not an inhibitor of the lectin activity. UEA II has no mitogenic activity and agglutinates type O erythrocytes with greater interest than type A3 erythrocytes. Addition of EDTA eliminates agglutinating activity. Agglutinating activity can be recovered with the addition of calcium.UEA II is a potent inhibitor of the lectin complement pathway following endothelial oxidative stress. The molecular mechanism of UEA II-induced inhibition of the lectin complement pathway appears to be through competition for a common binding site on the endothelial cell and not at the level of mannose-binding lectin (MBL) inhibition. See other UEA II conjugates.||Source:|Gorse||Blood Specificity:|Non-specific||Sugar Specificity:|Oligomers of beta(1,4) - linked N-Acetylglucosamine||Inhibitory Carbohydrate:|GlcNAc beta(1,4) GlcNAc||Divalent Ions:|Ca++, Mn++, Zn++||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Applications
Source: Gorse|Purity: Affinity purified|Form: Supplied as a lyophilized powder.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a lyophilized powder.
Purity
Affinity purified