Y27632 2 HCl [129830-38-2]

Référence AOB3877-10

Conditionnement : 10mg

Marque : AOBIOUS

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Y27632 2 HCl

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Data sheet

Molecular FormulaC14H23Cl2N3O
Molecular Weight320.26
CAS Numbers129830-38-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymY27632; Y-27632; Y 27632; Y27632 HCl; Y27632 dihydrochloride
IUPAC/Chemical Name(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
InChl KeyIDDDVXIUIXWAGJ-LJDSMOQUSA-N
InChl CodeInChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
SMILES CodeO=C([C@H]1CC[C@H]([C@H](N)C)CC1)NC2=CC=NC=C2.14Cl.14Cl
References1) Yang CY, et al., Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5859-70. doi: 10.1167/iovs.12-10930. PubMed PMID: 23920374; PubMed Central PMCID: PMC3757907.

2) Gandham VD, et al., Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782-6. doi: 10.1111/ced.12067. Epub 2013 May 16. PubMed PMID: 23675999; PubMed Central PMCID: PMC3748215.

More info

A selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

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