Anti-CD16/CD80 antibody (Clone: 3G8) {PE/TR}

Clonality:	Monoclonal
Clone ID:	3G8
Conjugation:	PE/TR
Isotype:	IgG1k
Formulation:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:	5 Mu L/Test
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	CD80
Gene ID:	941
Uniprot ID:	CD80_HUMAN

Tissue Specificity	Expressed on activated B-cells, macrophages and dendritic cells.
Post Translational Modifications	Palmitoylated by ZDHHC20.palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization.
Function	Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Protein Name	T-Lymphocyte Activation Antigen Cd80 Activation B7-1 Antigen Bb1 Ctla-4 Counter-Receptor B7.1 B7 Cd Antigen Cd80
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-389513 Reactome: R-HSA-6783783 Reactome: R-HSA-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Lymphocyte Activation Antigen Cd80 antibody Anti-Activation B7-1 Antigen antibody Anti-Bb1 antibody Anti-Ctla-4 Counter-Receptor B7.1 antibody Anti-B7 antibody Anti-Cd Antigen Cd80 antibody Anti-CD80 antibody Anti-CD28LG antibody Anti-CD28LG1 antibody Anti-LAB7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance