General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PFN1 (1-140) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | PFN1 |
| Gene ID: | 5216 |
| Uniprot ID: | PROF1_HUMAN |
| Immunogen Region: | 1-140 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human Profilin1 (NP_005013.1). |
| Immunogen Sequence: | MAGWNAYIDNLMADGTCQDA AIVGYKDSPSVWAAVPGKTF VNITPAEVGVLVGKDRSSFY VNGLTLGGQKCSVIRDSLLQ DGEFSMDLRTKSTGGAPTFN VTVTKTDKTLVLLMGKEGVH GGLINKKCYEMASHLRRSQY |
Description
| Tissue Specificity | Expressed in epididymis (at protein level). |
| Post Translational Modifications | Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation. |
| Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. |
| Protein Name | Profilin-1Epididymis Tissue Protein Li 184aProfilin I |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-376176Reactome: R-HSA-4086400Reactome: R-HSA-5663220 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Profilin-1 antibodyAnti-Epididymis Tissue Protein Li 184a antibodyAnti-Profilin I antibodyAnti-PFN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance