Anti-TICAM2 antibody (140-170) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.60-0.65 µg/µl
Dilution Range:	WB: 1:250 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TICAM2
Gene ID:	100302736/353376
Uniprot ID:	TCAM2_HUMAN
Immunogen Region:	140-170
Immunogen:	Synthetic peptide taken within amino acid region 140-170 on human TIRAP3b long form protein.

Tissue Specificity	Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
Post Translational Modifications	Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. Tyrosine phosphorylation is inhibited by phosphatase PTPN4. Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
Function	Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Protein Name	Tir Domain-Containing Adapter Molecule 2 Ticam-2 Putative Nf-Kappa-B-Activating Protein 502 Trif-Related Adapter Molecule Toll-Like Receptor Adaptor Protein 3 Toll/Interleukin-1 Receptor Domain-Containing Protein Myd88-4
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-166016 Reactome: R-HSA-166166 Reactome: R-HSA-2562578 Reactome: R-HSA-6798695 Reactome: R-HSA-936964 Reactome: R-HSA-937041 Reactome: R-HSA-937072 Reactome: R-HSA-975163
Cellular Localisation	Isoform 1: Cytoplasm Golgi Apparatus Cell Membrane Endoplasmic Reticulum Early Endosome Membrane Late Endosome Membrane Cell Projection Phagocytic Cup Localized To The Plasma Membrane As A Result Of Myristoylation Phosphorylation On Ser-16 Leads To Its Depletion From The Membrane Upon Lps Stimulation Colcoalizes With Isoform 2 In Late Endosomes Isoform 2: Endoplasmic Reticulum Translocates To Late Endosomes Upon Lps Stimulation Where It Colcoalizes With Isoform 1
Alternative Antibody Names	Anti-Tir Domain-Containing Adapter Molecule 2 antibody Anti-Ticam-2 antibody Anti-Putative Nf-Kappa-B-Activating Protein 502 antibody Anti-Trif-Related Adapter Molecule antibody Anti-Toll-Like Receptor Adaptor Protein 3 antibody Anti-Toll/Interleukin-1 Receptor Domain-Containing Protein antibody Anti-Myd88-4 antibody Anti-TICAM2 antibody Anti-TIRAP3 antibody Anti-TIRP antibody Anti-TRAM antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance