Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. Empire Genomics has developed a CAMTA1/WWTR1 Fusion FISH Probe that can be used to detect translocations between the CAMTA1 & WWTR1 genes. The probe comes labeled in green & red, and you may also choose to customize the probe to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
Gene Details
Gene Symbol: CAMTA1
Gene Name: Calmodulin Binding Transcription Activator 1
Chromosome: CHR1: 6845383-7829766
Locus: 1p36.31-p36.23