CCR8 (C-C Chemokine Receptor Type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC Chemokine Receptor CHEMR1, CDw198, Chemokine Receptor-like 1, CKRL1, CKR-L1, CMKBR8, CMKBRL2, CY6, GPRCY6, GPR-CY6, TER1) (PerCP)

Katalog-Nummer C2100-02C-100T

Size : 100Tests

Marke : US Biological

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C2100-02C CCR8 (C-C Chemokine Receptor Type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC Chemokine Receptor CHEMR1, CDw198, Chemokine Receptor-like 1, CKRL1, CKR-L1, CMKBR8, CMKBRL2, CY6, GPRCY6, GPR-CY6, TER1) (PerCP)

Clone Type
Polyclonal
Host
rat
Source
human
Swiss Prot
P51685
Isotype
IgG2b
Grade
Affinity Purified
Applications
FC
Crossreactivity
Hu Rt
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze

The human CCR8 chemokine receptor is a member of the rhodopsin superfamily of G protein-coupled receptors that span the cell membrane with seven hydrophobic transmembrane domains. CCR8, also known as TER1, ChemR1, and CKR-L1, is the receptor for the chemokine CCL1 (I-309). Three virally encoded ligands, vMIP-I, vMIP-II and vMCC-I, can also interact with the CCR8 receptor.3 CCR8 expression has been reported on peripheral blood monocytes, thymocytes and on Th2 polarized T cells.||Applications:|Suitable for use in Flow Cytometry. Other applications not tested.||Recommended Dilutions:|Flow Cytometry: 10ul labels 10e6 using human peripheral blood monocytes and rat peripheral blood cells|Optimal dilutions to be determined by the researcher.||Hybridoma:|Fusion of a mouse myeloma with B cells obtained from a rat immunized with BaF/3 cells transfected with human CCR8.||Absorption: |482nm||Emission: |564nm||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Caution: PerCP conjugates are sensitive to light.

Applications
Product Type: Mab|Isotype: IgG2b|Clone No: 10K39|Host: rat|Source: human|Concentration: ~0.05mg/ml|Form: Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with Peridinin-chlorophyll-protein complex (PerCP).|Purity: Purified by Protein G affinity chromatography from hybridoma culture supernatant|Immunogen: Recombinant protein corresponding to Met1-Asp355 from human CCR8 expressed in BaF3 pro-B cells.|Specificity: Recognizes human CCR8. Species Crossreactivity: rat. Neutralizes the bioactivity of human CCR8 and specifically stains human CCR8-transfected cell lines but not the parent cell lines.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Recombinant protein corresponding to Met1-Asp355 from human CCR8 expressed in BaF3 pro-B cells.
Form
Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with Peridinin-chlorophyll-protein complex (PerCP).
Purity
Purified by Protein G affinity chromatography from hybridoma culture supernatant
Specificity
Recognizes human CCR8. Species Crossreactivity: rat. Neutralizes the bioactivity of human CCR8 and specifically stains human CCR8-transfected cell lines but not the parent cell lines.
References
1. Roos, R.S. et al (1997) J. Biol. Chem. 272:17251. 2. Tiffany, H.L. et al. (1997) J. Exp. Med. 186:165. 3. Dairaghi, D.J. et al. (1999) J. Biol. Chem. 274:21569. 4. Napolitano, M. et al. (1996) J. Immunol. 157:2459. 5. Zaballos, A. et al. (1996) Biochem. Biophys. Res. Commun. 227:846. 6. D’Ambrosio, D. et al. (1998) J. Immunol. 161:111. 7. Zingoni, A. et al. (1998) J. Immunol. 161:547.