CLP290 [1181083-81-7]
Katalog-Nummer HY-103023-5mg
Size : 5mg
Marke : MedChemExpress
CLP290 is an orally available activator of the neuron-specific K+-Cl? cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats.
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CLP290 Chemische Struktur
CAS. Nr. : 1181083-81-7
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Beschreibung |
CLP290 is an orally available activator of the neuron-specific K+-Cl? cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ (HY-13753) rats[1][2]. |
IC50 & Target |
KCC2[1] |
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In Vivo |
CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl-?transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molekulargewicht |
404.46 |
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Formel |
C19H21FN4O3S |
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CAS. Nr. |
1181083-81-7 |
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Appearance |
Solid |
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Color |
Off-white to yellow |
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SMILES |
O=C(N1CCCC1)OC2=CC(F)=CC=C2/C=C(SC(N3CCCCN3)=N4)/C4=O |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 33.33 mg/mL (82.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.87% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.4724 mL | 12.3622 mL | 24.7243 mL | 61.8108 mL |
5 mM | 0.4945 mL | 2.4724 mL | 4.9449 mL | 12.3622 mL | |
10 mM | 0.2472 mL | 1.2362 mL | 2.4724 mL | 6.1811 mL | |
15 mM | 0.1648 mL | 0.8241 mL | 1.6483 mL | 4.1207 mL | |
20 mM | 0.1236 mL | 0.6181 mL | 1.2362 mL | 3.0905 mL | |
25 mM | 0.0989 mL | 0.4945 mL | 0.9890 mL | 2.4724 mL | |
30 mM | 0.0824 mL | 0.4121 mL | 0.8241 mL | 2.0604 mL | |
40 mM | 0.0618 mL | 0.3091 mL | 0.6181 mL | 1.5453 mL | |
50 mM | 0.0494 mL | 0.2472 mL | 0.4945 mL | 1.2362 mL | |
60 mM | 0.0412 mL | 0.2060 mL | 0.4121 mL | 1.0302 mL | |
80 mM | 0.0309 mL | 0.1545 mL | 0.3091 mL | 0.7726 mL |
CLP290 Related Classifications
- Membrane Transporter/Ion Channel
- Potassium Channel