DOPC

Biological Activity

1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid commonly used alone or with other components in the generation of micelles, liposomes, and other types of artificial membranes. It can be used in studies related to drug delivery.

Chemical Information

Molecular Weight	786.11
Formula	C44H84NO8P
CAS Number	4235-95-4
Storage	-20°C, dry, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gokce Alp, et al. J Liposome Res. Facile L-Glutamine delivery to erythrocytes via DOPC-DPPG mixed liposomes

[2] Inna Ermilova, et al. Phys Chem Chem Phys. DOPC versus DOPE as a helper lipid for gene-therapies: molecular dynamics simulations with DLin-MC3-DMA

[3] Mohammad Kaji Yazdi, et al. Anal Bioanal Chem. Design of a DOPC-MoS 2/AuNP hybrid as an organic bed with higher amplification for miR detection in electrochemical biosensors

[4] Laura J Fox, et al. Biochim Biophys Acta Gen Subj. Interactions between PAMAM dendrimers and DOPC lipid multilayers: Membrane thinning and structural disorder

[5] Nazar Ileri Ercan, et al. Langmuir. Molecular Dynamics Modeling of Methylene Blue-DOPC Lipid Bilayer Interactions