E2F1 Antibody - N-terminal region : HRP
Katalog-Nummer P100821_P050-HRP
Size : 100ul
Marke : Aviva Systems Biology
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Telefonnummer : +1 850 650 7790
E2F1 Antibody - N-terminal region (P100821_P050)
| Datasheets/Manuals | Printable datasheet for anti-E2F1 (P100821_P050) antibody |
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| Publications | Differential regulation of mammalian and avian ATOH1 by E2F1 and its implication for hair cell regeneration in the inner ear. Sci Rep. 11, 19368 (2021). 34588543 |
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| Tested Species Reactivity | Human |
| Predicted Species Reactivity | Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human E2F1 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: PARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWA |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-E2F1 (P100821_P050) antibody is Catalog # AAP31170 (Previous Catalog # AAPP01913) |
| Sample Type Confirmation | E2F1 is strongly supported by BioGPS gene expression data to be expressed in HEK293T |
| Reference | Hu,Y., (2008) Biochem. Biophys. Res. Commun. 370 (3), 440-444 |
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| Gene Symbol | E2F1 |
| Gene Full Name | E2F transcription factor 1 |
| Alias Symbols | RBP3, E2F-1, RBAP1, RBBP3 |
| NCBI Gene Id | 1869 |
| Protein Name | Transcription factor E2F1 |
| Description of Target | The protein encoded by E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Uniprot ID | Q01094 |
| Protein Accession # | NP_005216 |
| Nucleotide Accession # | NM_005225 |
| Protein Size (# AA) | 437 |
| Molecular Weight | 47kDa |
| Protein Interactions | RB1; SIRT1; KDM2A; LAMTOR5; EP300; KAT2B; VHL; RARA; STAT1; NCOR2; STOML1; RBL1; MAGEA11; SKP2; UHRF2; UBC; GTF2H1; ERCC3; SPT15; TFB1; TBP; NCOA3; CEBPE; PARP1; PRMT2; RBL2; CCNE1; TFDP2; TFDP1; CDKN2A; CEBPD; CDK2; CDK1; NEDD8; MCPH1; DDB2; DDB1; XIAP; |
