Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

EPO, recombinant Human

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Katalog-Nummer NB-50-0066-10

Size : 10µg

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Telefonnummer : +1 850 650 7790

Marke : Neo Biotech

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Contact local distributor :

Telefonnummer : +1 850 650 7790

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Bioassay analysis of Human EPO (Erythropoietin) Recombinant Protein, PeproTech® (Product # 100-64-1MG).

WHO Comparison of Human EPO (Erythropoietin) Recombinant Protein, PeproTech® (Product # 100-64-1MG).

Product Details

100-64-100UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

View 1 publication 1 publication

In vitro Assay (IV)

View 52 publications 52 publications

Miscellaneous PubMed (Misc)

View 9 publications 9 publications

Product Specifications

Species

Human

Published species

Human, Mouse, Virus

Expression System

CHO cells

Amino acid sequence

APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR

Molecular weight

18.4 kDa

Class

Recombinant

Type

Protein

Purity

≥ 90% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

PeproTech's Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth.

iScience

Xie X,Gou F,Zheng Z,Zhang Y,Zhang Y,Dong F,Cheng T,Cheng H

100-64 was used in Cell Culture to elucidate the dynamics of fetal hematopoiesis in preparation for birth, offering valuable insights into the pathological processes underlying leukemia.

Fri Aug 16 00:00:00 EDT 2024

CD34^dim cells identified as pluripotent stem cell-derived definitive hemogenic endothelium purified using bone morphogenetic protein 4.

Cell proliferation

Jeon SB,Han AR,Lee S,Lee SC,Lee MJ,Park SJ,Moon SH,Lee JY

100-64 was used in Cell Culture to develop a simple method to purify HE cells that were enriched in CD34dim cells.

Wed Feb 01 00:00:00 EST 2023

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.

Cancer discovery

Chen S,Vedula RS,Cuevas-Navarro A,Lu B,Hogg SJ,Wang E,Benbarche S,Knorr K,Kim WJ,Stanley RF,Cho H,Erickson C,Singer M,Cui D,Tittley S,Durham BH,Pavletich TS,Fiala E,Walsh MF,Inoue D,Monette S,Taylor J,Rosen N,McCormick F,Lindsley RC,Castel P,Abdel-Wahab O

100-64 was used in Cell Culture to reveal proteolysis of non-canonical RAS proteins as novel regulators of HSC self-renewal, define the function of RIT1 and LZTR1 mutations in leukemia, and identify means to overcome drug resistance due to LZTR1 downregulation.

Wed Oct 05 00:00:00 EDT 2022

Modeling human yolk sac hematopoiesis with pluripotent stem cells.

The Journal of experimental medicine

Atkins MH,Scarfò R,McGrath KE,Yang D,Palis J,Ditadi A,Keller GM

Mon Mar 07 00:00:00 EST 2022

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.

The Journal of experimental medicine

Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T

Mon Jan 03 00:00:00 EST 2022

Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.

Heart rhythm

Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ

100-64 was used in Cell Culture to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.

Sun May 01 00:00:00 EDT 2022

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.

RNA (New York, N.Y.)

Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF

100-64 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.

Thu Sep 01 00:00:00 EDT 2022

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells.

eLife

Vilaplana-Lopera N,Cuminetti V,Almaghrabi R,Papatzikas G,Rout AK,Jeeves M,González E,Alyahyawi Y,Cunningham A,Erdem A,Schnütgen F,Raghavan M,Potluri S,Cazier JB,Schuringa JJ,Reed MAC,Arranz L,Günther UL,Garcia P

100-64 was used in Cell Culture to present a unique metabolic communication between Acute Myleoid Leukaemia (AML) and stromal cells and propose two different molecular targets, Acetyl-CoA Synthestase 2 (ACSS2) and gap junctions, that could potentially be exploited for adjuvant therapy.

Fri Sep 02 00:00:00 EDT 2022

Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics.

Communications biology

Ito K,Matsuda Y,Mine A,Shikida N,Takahashi K,Miyairi K,Shimbo K,Kikuchi Y,Konishi A

Fri Jan 14 00:00:00 EST 2022

Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.

Cell discovery

Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L

100-64 was used in Cell Culture to demonstrate that interferon-mediated cell cycle control underlies the clinical efficacy of glucocorticoids.

Tue May 10 00:00:00 EDT 2022

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.

Cell stem cell

Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S

Thu Mar 04 00:00:00 EST 2021

Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.

The Journal of clinical investigation

Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T

100-64 was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.

Mon Feb 15 00:00:00 EST 2021

Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.

The Journal of clinical investigation

Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T

100-64 was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.

Mon Feb 15 00:00:00 EST 2021

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

Mon Feb 01 00:00:00 EST 2021

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

The Journal of experimental medicine

Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S

Mon Oct 04 00:00:00 EDT 2021

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.

The Journal of experimental medicine

Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E

Mon Jul 05 00:00:00 EDT 2021

Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.

Developmental cell

Ma Y,Liu S,Gao J,Chen C,Zhang X,Yuan H,Chen Z,Yin X,Sun C,Mao Y,Zhou F,Shao Y,Liu Q,Xu J,Cheng L,Yu D,Li P,Yi P,He J,Geng G,Guo Q,Si Y,Zhao H,Li H,Banes GL,Liu H,Nakamura Y,Kurita R,Huang Y,Wang X,Wang F,Fang G,Engel JD,Shi L,Zhang YE,Yu J

100-64 was used in Sample Preparation (FC/FACS) to investigate pseudogene phenotypic effects.

Mon Feb 22 00:00:00 EST 2021

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.

Blood advances

Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG

Tue Dec 14 00:00:00 EST 2021

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.

Nature communications

Zhang X,Luo M,Dastagir SR,Nixon M,Khamhoung A,Schmidt A,Lee A,Subbiah N,McLaughlin DC,Moore CL,Gribble M,Bayhi N,Amin V,Pepi R,Pawar S,Lyford TJ,Soman V,Mellen J,Carpenter CL,Turka LA,Wickham TJ,Chen TF

Tue May 11 00:00:00 EDT 2021

Methylation of dual-specificity phosphatase 4 controls cell differentiation.

Cell reports

Su H,Jiang M,Senevirathne C,Aluri S,Zhang T,Guo H,Xavier-Ferrucio J,Jin S,Tran NT,Liu SM,Sun CW,Zhu Y,Zhao Q,Chen Y,Cable L,Shen Y,Liu J,Qu CK,Han X,Klug CA,Bhatia R,Chen Y,Nimer SD,Zheng YG,Iancu-Rubin C,Jin J,Deng H,Krause DS,Xiang J,Verma A,Luo M,Zhao X

Tue Jul 27 00:00:00 EDT 2021

In vitro expansion of fetal liver hematopoietic stem cells.

Scientific reports

Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V

Fri Jun 04 00:00:00 EDT 2021

Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.

Nature communications

Georgolopoulos G,Psatha N,Iwata M,Nishida A,Som T,Yiangou M,Stamatoyannopoulos JA,Vierstra J

Tue Nov 23 00:00:00 EST 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Nature communications

Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM

Mon Mar 01 00:00:00 EST 2021

Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.

iScience

de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG

Fri Aug 20 00:00:00 EDT 2021

Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson's Disease.

Antioxidants (Basel, Switzerland)

Rey F,Ottolenghi S,Giallongo T,Balsari A,Martinelli C,Rey R,Allevi R,Giulio AMD,Zuccotti GV,Mazzucchelli S,Foresti R,Samaja M,Carelli S

100-64 was used in Sample Preparation to investigate use of erythropoietin to treat Parkinson’s.

Fri Jan 15 00:00:00 EST 2021

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.

Cancer discovery

Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A

100-64 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.

Tue Dec 01 00:00:00 EST 2020

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.

Cell stem cell

Ortmann D,Brown S,Czechanski A,Aydin S,Muraro D,Huang Y,Tomaz RA,Osnato A,Canu G,Wesley BT,Skelly DA,Stegle O,Choi T,Churchill GA,Baker CL,Rugg-Gunn PJ,Munger SC,Reinholdt LG,Vallier L

100-64 was used in Cell Culture to investigate the variability in experimental reproducibility of pluripotent stem cell lines in mice.

Thu Sep 03 00:00:00 EDT 2020

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.

Cell stem cell

Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A

100-64 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.

Thu Nov 05 00:00:00 EST 2020

Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

EMBO reports

Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A

Wed Feb 05 00:00:00 EST 2020

Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

EMBO reports

Wed Feb 05 00:00:00 EST 2020

Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins.

Nature communications

Pavani G,Laurent M,Fabiano A,Cantelli E,Sakkal A,Corre G,Lenting PJ,Concordet JP,Toueille M,Miccio A,Amendola M

Wed Jul 29 00:00:00 EDT 2020

Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.

eLife

Cendrowski J,Kaczmarek M,Mazur M,Kuzmicz-Kowalska K,Jastrzebski K,Brewinska-Olchowik M,Kominek A,Piwocka K,Miaczynska M

100-64 was used in Cell Culture to investigate the role of the longer(L) and shorter(S) splicing variant of bone morphogenetic protein 2-inducible kinase(BMP2K) in endocytosis and cell differentiation.

Fri Aug 14 00:00:00 EDT 2020

Inhibition of red blood cell development by arsenic-induced disruption of GATA-1.

Scientific reports

Zhou X,Medina S,Bolt AM,Zhang H,Wan G,Xu H,Lauer FT,Wang SC,Burchiel SW,Liu KJ

Wed Nov 04 00:00:00 EST 2020

JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors.

American journal of physiology. Renal physiology

Wakashima T,Tanaka T,Fukui K,Komoda Y,Shinozaki Y,Kobayashi H,Matsuo A,Nangaku M

Wed Jan 01 00:00:00 EST 2020

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.

Immunity

Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V

Tue Jul 16 00:00:00 EDT 2019

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.

Blood

Hu T,Morita K,Hill MC,Jiang Y,Kitano A,Saito Y,Wang F,Mao X,Hoegenauer KA,Morishita K,Martin JF,Futreal PA,Takahashi K,Nakada D

Thu Aug 15 00:00:00 EDT 2019

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.

Blood

Sasca D,Yun H,Giotopoulos G,Szybinski J,Evan T,Wilson NK,Gerstung M,Gallipoli P,Green AR,Hills R,Russell N,Osborne CS,Papaemmanuil E,Göttgens B,Campbell P,Huntly BJP

Thu Dec 12 00:00:00 EST 2019

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Cell stem cell

Yamashita M,Passegué E

100-64 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.

Thu Sep 05 00:00:00 EDT 2019

Gene correction for SCID-X1 in long-term hematopoietic stem cells.

Nature communications

Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH

100-64 was used in In vitro experiments to evaluate the use of SCID-X1 in targeting the cDNA in human long-term hematopoietic stem cells.

Tue Apr 09 00:00:00 EDT 2019

N⁶-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis.

Nature communications

Kuppers DA,Arora S,Lim Y,Lim AR,Carter LM,Corrin PD,Plaisier CL,Basom R,Delrow JJ,Wang S,Hansen He H,Torok-Storb B,Hsieh AC,Paddison PJ

Thu Oct 10 00:00:00 EDT 2019

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.

Immunity

Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z

Tue Apr 17 00:00:00 EDT 2018

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.

The Journal of clinical investigation

Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R

Mon Apr 02 00:00:00 EDT 2018

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.

The Journal of clinical investigation

Mon Apr 02 00:00:00 EDT 2018

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.

The Journal of clinical investigation

Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC

Mon Dec 03 00:00:00 EST 2018

Revealing nascent proteomics in signaling pathways and cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Forester CM,Zhao Q,Phillips NJ,Urisman A,Chalkley RJ,Oses-Prieto JA,Zhang L,Ruggero D,Burlingame AL

Tue Mar 06 00:00:00 EST 2018

Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.

Journal of immunology (Baltimore, Md. : 1950)

Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA

Thu Feb 01 00:00:00 EST 2018

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature communications

Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II

Tue May 08 00:00:00 EDT 2018

Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.

Stem cell reports

Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR

Tue Nov 13 00:00:00 EST 2018

Reconstruction of complex single-cell trajectories using CellRouter.

Nature communications

Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ

Thu Mar 01 00:00:00 EST 2018

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.

Cell discovery

Rothberg JLM,Maganti HB,Jrade H,Porter CJ,Palidwor GA,Cafariello C,Battaion HL,Khan ST,Perkins TJ,Paulson RF,Ito CY,Stanford WL

Thu Aug 17 00:00:00 EDT 2023

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 EDT 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Stem cells translational medicine

Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP

Wed Mar 01 00:00:00 EST 2017

Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.

Stem cell reports

Wen W,Zhang JP,Xu J,Su RJ,Neises A,Ji GZ,Yuan W,Cheng T,Zhang XB

Tue Jun 14 00:00:00 EDT 2016

Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.

Stem cell reports

Saxena S,Rönn RE,Guibentif C,Moraghebi R,Woods NB

Tue May 10 00:00:00 EDT 2016

T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.

Blood

Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y

Thu Jan 08 00:00:00 EST 2015

Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.

The Journal of experimental medicine

Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z

Mon Dec 14 00:00:00 EST 2015

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Stem cells (Dayton, Ohio)

Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW

Fri May 01 00:00:00 EDT 2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Stem cells (Dayton, Ohio)

Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y

Sun Mar 01 00:00:00 EST 2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Stem cells (Dayton, Ohio)

Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y