GS-441524

Katalog-Nummer AOB36496-50

Size : 50mg

Marke : AOBIOUS

Weitere Informationen anfordern

Contact local distributor :


Telefonnummer : +1 850 650 7790

GS-441524

Quantity Discount Table - Order More To Get More Discount

Data sheet

Molecular FormulaC12H13N5O4
Molecular Weight291.27
CAS Numbers1191237-69-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymGS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite
IUPAC/Chemical Name(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
InChl KeyBRDWIEOJOWJCLU-LTGWCKQJSA-N
InChl CodeInChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
SMILES CodeN#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@H](CO)[C@@H](O)[C@H]1O
References1) Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281.

2) Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233.

More info

A novel precursor of potent inhibitor of feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. It only becomes effective pharmacologically when it was formed as its triphosphate analog in situ.


GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.


REFERENCE:

1) Murphy BG, etc. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 219:226-233 (2018). doi: 10.1016/j.vetmic.2018.04.026. Epub 2018 Apr 22. PubMed PMID: 29778200

2) J Feline Med Surg. 2019 Apr; 21(4): 271–281.

3) Dr. Perdersen Recent Update

Sie könnten auch an folgenden Produkten interessiert sein:



Katalog-Nummer
Beschreibung
Cond.
Preis zzgl. MwSt.
A17170-10
 10mg 
544028-100mg
 100mg