Human RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	RYR1
Gene ID:	6261
Uniprot ID:	RYR1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Skeletal muscle and brain (cerebellum and hippocampus).
Post Translational Modifications	Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation.
Function	Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Protein Name	Ryanodine Receptor 1 Ryr-1 Ryr1 Skeletal Muscle Calcium Release Channel Skeletal Muscle Ryanodine Receptor Skeletal Muscle-Type Ryanodine Receptor Type 1 Ryanodine Receptor
Database Links	Reactome: R-HSA-2672351 Reactome: R-HSA-5578775
Cellular Localisation	Sarcoplasmic Reticulum Membrane Multi-Pass Membrane Protein The Number Of Predicted Transmembrane Domains Varies Between Orthologs Both N-Terminus And C-Terminus Are Cytoplasmic
Alternative ELISA Names	Ryanodine Receptor 1 ELISA kit Ryr-1 ELISA kit Ryr1 ELISA kit Skeletal Muscle Calcium Release Channel ELISA kit Skeletal Muscle Ryanodine Receptor ELISA kit Skeletal Muscle-Type Ryanodine Receptor ELISA kit Type 1 Ryanodine Receptor ELISA kit RYR1 ELISA kit RYDR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance