Levofloxacin [100986-85-4]
Katalog-Nummer HY-B0330-5g
Size : 5g
Marke : MedChemExpress
Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Levofloxacin Chemische Struktur
CAS. Nr. : 100986-85-4
This product is a controlled substance and not for sale in your territory.
Based on 8 publication(s) in Google Scholar
Other Forms of Levofloxacin:
- Ofloxacin In-stock
- Levofloxacin hydrate In-stock
- Levofloxacin hydrochloride In-stock
- (R)-Ofloxacin In-stock
- Levofloxacin-d8 In-stock
- (S)-Ofloxacin-d3 In-stock
- Levofloxacin-13C,d3 In-stock
- Levofloxacin sodium Angebot einholen
Alle Topoisomerase Isoform-spezifische Produkte anzeigen:
Alle Antibiotic Isoform-spezifische Produkte anzeigen:
Beschreibung |
Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity[1][2][3][4][5]. |
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IC50 & Target |
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In Vitro |
Levofloxacin shows inhibition effects to M. tuberculosis susceptible strains OFLO, LVFX, and SPFX with MIC50 values of 1.0, 0.5 and 0.25 μg/mL, respectively[4]。 MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Levofloxacin (10.7 mg/kg; i.p., once daily for 10 days or 3 weeks) time-dependently induces toxic effects on liver and heart in albino mice[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Klinische Studie |
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Molekulargewicht |
361.37 |
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Formel |
C18H20FN3O4 |
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CAS. Nr. |
100986-85-4 |
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Appearance |
Solid |
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Color |
Off-white to light yellow |
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SMILES |
O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 10 mg/mL (27.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 5 mg/mL (13.84 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.93% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.7672 mL | 13.8362 mL | 27.6725 mL | 69.1812 mL |
5 mM | 0.5534 mL | 2.7672 mL | 5.5345 mL | 13.8362 mL | |
10 mM | 0.2767 mL | 1.3836 mL | 2.7672 mL | 6.9181 mL | |
DMSO | 15 mM | 0.1845 mL | 0.9224 mL | 1.8448 mL | 4.6121 mL |
20 mM | 0.1384 mL | 0.6918 mL | 1.3836 mL | 3.4591 mL | |
25 mM | 0.1107 mL | 0.5534 mL | 1.1069 mL | 2.7672 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Levofloxacin Related Classifications
- Cell Cycle/DNA Damage Anti-infection
- Topoisomerase DNA/RNA Synthesis Antibiotic Bacterial Orthopoxvirus