Mouse CACNa1C (Calcium Channel, Voltage Dependent, L-Type, Alpha 1C Subunit) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Cacna1c
Gene ID:	12288
Uniprot ID:	CAC1C_MOUSE
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity	Detected in embryonic heart. Detected in retina in rod bipolar cells. Detected in tibialis artery (at protein level). Detected in smooth muscle cells from tibialis artery and in mesenteric artery. High expression in heart, followed by brain and spinal cord.
Post Translational Modifications	Phosphorylation by PKA at Ser-1897 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.
Function	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Protein Name	Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle Melc-Cc Mouse Brain Class C Mbc Voltage-Gated Calcium Channel Subunit Alpha Cav1.2
Database Links	Reactome: R-MMU-422356 Reactome: -MMU-5576892 Reactome: -MMU-5576893
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Sarcolemma Perikaryon Postsynaptic Density Membrane Cell Projection Dendrite T-Tubule Colocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional Membrane Where The Sarcolemma And The Sarcoplasmic Reticulum Are In Close Contact The Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane Localized In T-Tubules As Shown In Serca2-Knockout Cardiomyocytes
Alternative ELISA Names	Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c ELISA kit Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle ELISA kit Melc-Cc ELISA kit Mouse Brain Class C ELISA kit Mbc ELISA kit Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 ELISA kit Cacna1c ELISA kit Cach2 ELISA kit Cacn2 ELISA kit Cacnl1a1 ELISA kit Cchl1a1 ELISA kit
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Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance