Mouse RYR1 (Ryanodine Receptor 1, Skeletal) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Ryr1
Gene ID:	20190
Uniprot ID:	RYR1_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Detected in muscle and myotubes (at protein level). Ubiquitous. Detected in diaphragm, skeletal muscle, esophagus, spleen, submaxillary gland, adrenal gland, cerebellum, brain and in testis germ cells.
Post Translational Modifications	Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2844 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2844. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation.
Function	Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Protein Name	Ryanodine Receptor 1 Ryr-1 Ryr1 Skeletal Muscle Calcium Release Channel Skeletal Muscle Ryanodine Receptor Skeletal Muscle-Type Ryanodine Receptor Type 1 Ryanodine Receptor
Database Links	Reactome: R-MMU-2672351 Reactome: -MMU-5578775
Cellular Localisation	Sarcoplasmic Reticulum Membrane Multi-Pass Membrane Protein The Number Of Predicted Transmembrane Domains Varies Between Orthologs Both N-Terminus And C-Terminus Are Cytoplasmic
Alternative ELISA Names	Ryanodine Receptor 1 ELISA kit Ryr-1 ELISA kit Ryr1 ELISA kit Skeletal Muscle Calcium Release Channel ELISA kit Skeletal Muscle Ryanodine Receptor ELISA kit Skeletal Muscle-Type Ryanodine Receptor ELISA kit Type 1 Ryanodine Receptor ELISA kit Ryr1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance