Application
| WB, IP, ICC |
---|---|
Primary Accession | Q15418 |
Other Accession | NP_002944.2 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat, Bovine |
Clonality | Polyclonal |
Description | Rabbit Anti-Human p90 RSK1 Polyclonal |
Target/Specificity | Detects ~90kDa. |
Other Names | RSK1 p90 Antibody, HU1 Antibody, MAPKAP Antibody, p90rsk Antibody, p90S6K Antibody, RSK1 Antibody, RSK 1 p90 Antibody |
Immunogen | Human p90 RSK1 C-terminal peptide, conjugated to KLH |
Purification | Protein A Purified |
Storage | -20ºC |
Storage Buffer | TBS, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | 0.25 mg/ml was sufficient for detection of SPC-147 in lysates prepared from mouse brain, spleen and intestine. |
Cellular Localization | Cytoplasm | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1–4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
References
1. Roux, P. (2007). UCSD-Nature Molecule Pages.
2. Fro¨din, M. and Gammeltoft, S. (1999) Mol. Cell. Endocrinol. 151: 65-77.
3. Merienne, K. et al. (1998) J. Med. Genet. 35: 890-894.
4. De Cesare, D. et al. (1998) Proc. Natl. Acad. Sci. 95: 12202-12207.
5. Joel, P. B. et al. (1998) Mol. Cell. Biol. 18: 1978-1984.