PAX6 (NM_001604) Human Recombinant Protein
Katalog-Nummer TP760453
Size : 50ug
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PAX6 (NM_001604) Human Recombinant Protein
SKU
TP760453
Purified recombinant protein of Human paired box 6 (PAX6), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
In Stock*
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | Protein Sequence A DNA sequence encoding human full-length PAX6 |
| Tag | N-His |
| Predicted MW | 48 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_001595 |
| Locus ID | 5080 |
| UniProt ID | P26367 |
| Cytogenetics | 11p13 |
| RefSeq Size | 2781 |
| RefSeq ORF | 1308 |
| Synonyms | AN; AN1; AN2; ASGD5; D11S812E; FVH1; MGDA; WAGR |
| Summary | This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019] |
| Protein Families | Adult stem cells, Druggable Genome, Embryonic stem cells, Transcription Factors |
| Protein Pathways | Maturity onset diabetes of the young |
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Recombinant Protein Resources |
| SKU | Description | Size | ||
|---|---|---|---|---|
| LC400107 | PAX6 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug | | |
| LC419854 | PAX6 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug | | |
| LY400107 | Transient overexpression lysate of paired box 6 (PAX6), transcript variant 1 | 100 ug | | |
| LY419854 | Transient overexpression lysate of paired box 6 (PAX6), transcript variant 2 | 100 ug | | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.