PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation. [[922507-80-0]]
Katalog-Nummer orb1909999-500mg
Size : 500mg
Marke : Biorbyt
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PDI inhibitor 16F16
Catalog Number: orb1909999
| Catalog Number | orb1909999 |
|---|---|
| Category | Small Molecules |
| Description | PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation. |
| CAS Number | [922507-80-0] |
| MW | 320.770783185959 |
| SMILES | ClCC(N1CCC2C3=CC=CC=C3NC=2C1(C)C(OC)=O)=O |
| Formula | C16H17CLN2O3 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |