Propranolol [525-66-6]
Katalog-Nummer HY-B0573B-100mg
Size : 100mg
Marke : MedChemExpress
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Propranolol Chemische Struktur
CAS. Nr. : 525-66-6
This product is a controlled substance and not for sale in your territory.
Based on 21 publication(s) in Google Scholar
Other Forms of Propranolol:
- Propranolol hydrochloride In-stock
- Propranolol-d7 In-stock
Beschreibung |
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. |
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IC50 & Target |
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In Vitro |
Propranolol (10-7 M-10-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10-5 M in HemSCs[4].? Propranolol (10-9 M-10-3 M; 24 and 48 hours) significant decreases cell proliferation at 10-4 M propranolol after 24 hours and 10-9 M propranolol after 48 hours in HemSCs[4].? Propranolol (50 μM-200 μM;24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[4]
Cell Proliferation Assay[4]
Apoptosis Analysis[4]
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In Vivo |
Propranolol (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Klinische Studie |
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Molekulargewicht |
259.34 |
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Formel |
C16H21NO2 |
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CAS. Nr. |
525-66-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OC(COC1=C2C=CC=CC2=CC=C1)CNC(C)C |
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Structure Classification |
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Initial Source |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 100 mg/mL (385.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.87% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.8559 mL | 19.2797 mL | 38.5594 mL | 96.3986 mL |
5 mM | 0.7712 mL | 3.8559 mL | 7.7119 mL | 19.2797 mL | |
10 mM | 0.3856 mL | 1.9280 mL | 3.8559 mL | 9.6399 mL | |
15 mM | 0.2571 mL | 1.2853 mL | 2.5706 mL | 6.4266 mL | |
20 mM | 0.1928 mL | 0.9640 mL | 1.9280 mL | 4.8199 mL | |
25 mM | 0.1542 mL | 0.7712 mL | 1.5424 mL | 3.8559 mL | |
30 mM | 0.1285 mL | 0.6427 mL | 1.2853 mL | 3.2133 mL | |
40 mM | 0.0964 mL | 0.4820 mL | 0.9640 mL | 2.4100 mL | |
50 mM | 0.0771 mL | 0.3856 mL | 0.7712 mL | 1.9280 mL | |
60 mM | 0.0643 mL | 0.3213 mL | 0.6427 mL | 1.6066 mL | |
80 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2050 mL | |
100 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9640 mL |
Propranolol Related Classifications
- GPCR/G Protein Neuronal Signaling Anti-infection
- Adrenergic Receptor Bacterial