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> Streptomycin (sulfate) [3810-74-0]

Streptomycin (sulfate) [3810-74-0]

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Katalog-Nummer HY-B0472-10g

Size : 10g

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Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

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Streptomycin sulfate Chemische Struktur

Streptomycin sulfate Chemische Struktur

CAS. Nr. : 3810-74-0

This product is a controlled substance and not for sale in your territory.

Based on 17 publication(s) in Google Scholar

Other Forms of Streptomycin sulfate:

  • Streptomycin In-stock

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Beschreibung

Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

IC50 & Target

Aminoglycoside

 

In Vitro

Strain RB1 shows enhanced susceptibility to streptomycin as the concentration of CV in the growth medium increases. As the CV concentration in the growth medium increases, both cytochrome aa3 levels and streptomycin susceptibility increase. Cytochrome aa3 is necessary for accumulation of streptomycin by B. subtilis[1]. Streptomycin influences tRNA selection. Streptomycin resistance mutations generally map to protein S12 and most of these variants exhibit increased levels of discrimination in the tRNA selection process[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Streptomycin sulfate Related Antibodies
Klinische Studie
Molekulargewicht

728.69

Formel

C21H42N7O18S1.5
CAS. Nr.

3810-74-0
Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(C=O)[C@H]([C@@H](O[C@H]1C)O[C@]([C@@H]([C@@H](O)[C@@H]2NC(N)=N)O)(11)[C@H]([C@@H]2O)NC(N)=N)O[C@@](O[C@@H](CO)[C@H](O)[C@H]3O)(11)[C@H]3NC.[1.5H2SO4]
Structure Classification
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Other Antibiotics
  • Antibiotics
  • Plant agriculture research
  • Antibiotics
  • Plant Cell Culture
  • Antibiotics
  • Resistance Selection
Initial Source
  • Microorganisms

Streptomyces
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : ≥ 100 mg/mL (137.23 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3723 mL 6.8616 mL 13.7233 mL
5 mM 0.2745 mL 1.3723 mL 2.7447 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (137.23 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: ≥98.0%

COA (262 KB) HNMR (202 KB)

Handling Instructions (2659 KB)
Verweise

  • [1]. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12.  [Content Brief]

    [2]. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76.  [Content Brief]

  • [1]. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12.

    [2]. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3723 mL 6.8616 mL 13.7233 mL 34.3081 mL
5 mM 0.2745 mL 1.3723 mL 2.7447 mL 6.8616 mL
10 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4308 mL
15 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
20 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
25 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL
30 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1436 mL
40 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8577 mL
50 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.6862 mL
60 mM 0.0229 mL 0.1144 mL 0.2287 mL 0.5718 mL
80 mM 0.0172 mL 0.0858 mL 0.1715 mL 0.4289 mL
100 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.3431 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Streptomycin sulfate Related Classifications

  • Anti-infection
  • Bacterial Antibiotic
Help & FAQs

Keywords:

Streptomycin3810-74-0BacterialAntibioticInhibitorinhibitorinhibit

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