UZH2 [2756566-45-5]
Katalog-Nummer HY-115717-10mg
Size : 10mg
Marke : MedChemExpress
UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.
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UZH2 Chemische Struktur
CAS. Nr. : 2756566-45-5
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Beschreibung |
UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM. |
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In Vitro |
UZH2 (compound 22) (0-25 μM, 1 h) stabilizes METTL3 in a dosedependent manner at 54 °C, with an EC50 of 0.85 μM in MOLM-13 cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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Molekulargewicht |
513.63 |
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Formel |
C27H37F2N7O |
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CAS. Nr. |
2756566-45-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
CNC1=NC=NC(N2CCC3(CN(CC(N3)=O)C4=C(C=C(C(F)=C4)CN5CCC(C)(CC5)C)F)CC2)=C1 |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 50 mg/mL (97.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation | |||||||||||||
Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.9469 mL | 9.7346 mL | 19.4693 mL | 48.6732 mL |
5 mM | 0.3894 mL | 1.9469 mL | 3.8939 mL | 9.7346 mL | |
10 mM | 0.1947 mL | 0.9735 mL | 1.9469 mL | 4.8673 mL | |
15 mM | 0.1298 mL | 0.6490 mL | 1.2980 mL | 3.2449 mL | |
20 mM | 0.0973 mL | 0.4867 mL | 0.9735 mL | 2.4337 mL | |
25 mM | 0.0779 mL | 0.3894 mL | 0.7788 mL | 1.9469 mL | |
30 mM | 0.0649 mL | 0.3245 mL | 0.6490 mL | 1.6224 mL | |
40 mM | 0.0487 mL | 0.2434 mL | 0.4867 mL | 1.2168 mL | |
50 mM | 0.0389 mL | 0.1947 mL | 0.3894 mL | 0.9735 mL | |
60 mM | 0.0324 mL | 0.1622 mL | 0.3245 mL | 0.8112 mL | |
80 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6084 mL |