Anti-IL17RC antibody (70-120) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.80-1.1 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	IL17RC
Gene ID:	84818
Uniprot ID:	I17RC_HUMAN
Immunogen Region:	70-120
Immunogen:	Synthetic peptide taken within amino acid region 70-120 on IL17RC1 protein common to C2 and C5.

Function	Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway. Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Isoform 5: Receptor for both IL17A and IL17F. Isoform 6: Does not bind IL17A or IL17F. Isoform 7: Does not bind IL17A or IL17F. Isoform 8: Receptor for both IL17A and IL17F.
Protein Name	Interleukin-17 Receptor C Il-17 Receptor C Il-17rc Interleukin-17 Receptor Homolog Il17rhom Interleukin-17 Receptor-Like Protein Il-17rl Zcytor14
Database Links	Reactome: R-HSA-448424 Reactome: R-HSA-9705671
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Soluble Isoforms May Be Produced
Alternative Antibody Names	Anti-Interleukin-17 Receptor C antibody Anti-Il-17 Receptor C antibody Anti-Il-17rc antibody Anti-Interleukin-17 Receptor Homolog antibody Anti-Il17rhom antibody Anti-Interleukin-17 Receptor-Like Protein antibody Anti-Il-17rl antibody Anti-Zcytor14 antibody Anti-IL17RC antibody Anti-UNQ6118 antibody Anti-PRO20040 antibody Anti-PRO38901 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance