Dabigatran Etexilate

Biological Activity

BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. It is being studied for various clinical indications and in many cases it offers an alternative to warfarin as the preferred orally administered blood thinner since it does not require prothrombin time monitoring while offering similar results in terms of efficacy.

Chemical Information

Molecular Weight	627.73
Formula	C34H41N7O5
CAS Number	211915-06-9
Solubility (25°C)	DMSO 96 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Jacqueline Halton, et al. Dabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority trial

[2] Giulio Francesco Romiti, et al. A comprehensive appraisal of dabigatran etexilate clinical evidence and applications: a 10-year-long story

[3] Leonardo R Brando, et al. Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children

[4] Jos M Ferro, et al. Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis: A Randomized Clinical Trial

[5] Hannah A Blair, et al. Dabigatran Etexilate: A Review in Nonvalvular Atrial Fibrillation