Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie
 
> Imeglimin [775351-65-0]

Imeglimin [775351-65-0]

Drucken Drucken
Melden Sie sich an

Katalog-Nummer HY-14771-5mg

Size : 5mg

Marke : MedChemExpress

Weitere Informationen anfordern

Contact local distributor :


Telefonnummer : +1 850 650 7790

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Imeglimin hydrochloride) that retains the same biological activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Imeglimin Chemische Struktur

Imeglimin Chemische Struktur

CAS. Nr. : 775351-65-0

Größe Verfügbarkeit
50 mg   Angebot einholen  
100 mg   Angebot einholen  
250 mg   Angebot einholen  
Synthetic products have potential research and development risk.

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Imeglimin:

Imeglimin hydrochloride
Beschreibung

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

IC50 & Target

ROS; mitochondrial function[1]
In Vitro

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imeglimin Related Antibodies

Cell Viability Assay[2]

Cell Line: Human endothelial cells (HMEC-1)
Concentration: 100 μM and10 mM
Incubation Time: 100 μM for 24 h, 10 mM for 4 h
Result: Prevention of cell death.
In Vivo

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage: 200 mg/kg
Administration: Oral gavage; b.i.d.; 6 weeks
Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
Klinische Studie
Molekulargewicht

155.20

Formel

C6H13N5
CAS. Nr.

775351-65-0

SMILES

NC1=N[C@@H](C)N=C(N(C)C)N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise

  • [1]. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64.  [Content Brief]

    [2]. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.  [Content Brief]

  • [1]. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64.

    [2]. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Imeglimin Related Classifications

  • Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  • Mitochondrial Metabolism Reactive Oxygen Species

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs

  • Keywords:

    Imeglimin775351-65-0EMD 387008EMD387008EMD-387008Mitochondrial MetabolismReactive Oxygen SpeciesoralglucoseloweringinsulinsensitivityROSmitochondrialfunctionInhibitorinhibitorinhibit

Sie könnten auch an folgenden Produkten interessiert sein:



Katalog-Nummer
Beschreibung
Cond.
Preis zzgl. MwSt.
CC-80639
Mouse Haptoglobin ELISA Kit
 96tests 
CC-80569
Mouse Adiponectin ELISA Kit
 96tests 
B1212-5mg
Imeglimin [775351-65-0]
 5mg