Application
| IHC-P, FC |
|---|---|
| Primary Accession | P35900 |
| Reactivity | Human, Rat, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | IT-Ks 20.10 |
| Calculated MW | 48kDa |
| Dilution | IHC-P (1:50) |
| Gene ID | 54474 |
|---|---|
| Other Names | Keratin, type I cytoskeletal 20, Cytokeratin-20, CK-20, Keratin-20, K20, Protein IT, KRT20 |
| Target/Specificity | Human, pig, and rat. Polypeptide reacting: Protein IT Reactivities on cultured Cell lines that have been tested so far are HT-29, LoVo, DLD-1, SW 1116 CaCo-2, RT-4. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | KRT20 / CK20 / Cytokeratin 20 Antibody (clone IT-Ks 20.10, FITC) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT20 |
|---|---|
| Function | Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa |
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Background
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
References
Moll R.,et al.Differentiation 53:75-93(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhou Q.,et al.J. Biol. Chem. 281:16453-16461(2006).
Calnek D.,et al.Differentiation 53:95-104(1993).
Moll R.,et al.J. Cell Biol. 111:567-580(1990).