Mouse Anti-Human GFAP-HRP
Katalog-Nummer 12075-05
Size : 1.0mL
Marke : Southern Biotech
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| Clone | SB61b |
|---|---|
| Isotype | Mouse (BALB/c) IgG2bκ |
| Isotype Control | Mouse IgG2b-HRP (A-1) |
| Specificity | Human/Mouse GFAP |
| Alternative Names | Glial fibrillary acidic protein, intermediate filament protein |
| Description | Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer’s disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system. |
| Immunogen | Recombinant human GFAP |
| Conjugate | HRP (Horseradish Peroxidase) |
| Buffer Formulation | 50% Glycerol/50% Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Immunocytochemistry – Quality tested Immunohistochemistry-Frozen Sections – Reported in literature 1 Western Blot 2 ELISA-Detection 2 Note – May be paired with the purified clone SB61a (SB Cat. No. 12070-01) in a sandwich ELISA |
| RRID Number | AB_2794712 |
| Gene ID | 2670 (Human) 14580 (Mouse) |
| Gene ID Symbol | GFAP (Human) Gfap (Mouse) |
| Gene ID Aliases | ALXDRD; AI836096 |
| UniProt ID | P14136 (Human P03995 (Mouse |
| UniProt Name | GFAP_HUMAN (Human) GFAP_MOUSE (Mouse) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 1. Pons-Espinal M, de Lagran MM, Dierssen M. Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A. Neurobiol Dis. 2013;60:18-31. (IHC-FS, Mouse Reactivity)
- 2. SouthernBiotech unpublished data (WB, ELISA)