NMDA 2b Receptor (NMDA R2b, N-methyl-D-aspartate, GRIN2B, Glutamate Receptor Ionotropic N-methyl D-aspartate 2B, HGNC:4586, NR2B, hNR3, N-methyl-D-aspartate Receptor Subunit 2B) (APC)

Katalog-Nummer N2905-41-APC-100ul

Size : 100ul

Marke : US Biological

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N2905-41-APC NMDA 2b Receptor (NMDA R2b, N-methyl-D-aspartate, GRIN2B, Glutamate Receptor Ionotropic N-methyl D-aspartate 2B, HGNC:4586, NR2B, hNR3, N-methyl-D-aspartate Receptor Subunit 2B) (APC)

Clone Type
Polyclonal
Host
mouse
Source
human
Isotype
IgG1
Grade
Affinity Purified
Applications
FLISA IHC WB
Crossreactivity
Ca Hu Mk Rt
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze

N-methyl-D-Aspartate (NMDA) type receptors are glutamate-activated calcium channels that play central roles in brain function and disease. Activation of NMDA receptors leads to elevations in synaptic calcium levels, initiating a series of calcium dependent signaling events including activation of nitric oxide synthase and stimulation of calcium/calmodulin dependent protein kinase, and MAP kinase cascades. Through these signal transduction pathways, NMDA receptors mediate both synaptic plasticity and learning and memory. NMDA receptors are composed of multiple subunits. The subunits are thought to co-assemble in different combinations to form functionally distinct NMDA receptors. All receptors contain an NR1 subunit and various numbers of NR2 subunits. NR2b is the major subunit expressed in adult forebrain. NR2 is also a major component of the postsynaptic density in hippocampus and cerebral cortex. The NR2 subunit class consists of four genes encoding the subunits NR2A-NR2D. In addition to mediating diverse aspects of synaptic physiology, NMDA receptors also play a major role in neuro degnerative diseases. Overactivity of NMDA receptors in implicated in numerous neurodegenerative processes including stroke, Alzheimer’s disease, Huntington’s chorea, and amyotrophic lateral sclerosis.||Applications: |Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.||Recommended Dilutions:|Immunohistochemistry: Frozen sections|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. ||Note: Applications are based on unconjugated antibody.

Applications
Product Type: Mab|Isotype: IgG1|Clone No: 3G213|Host: mouse|Source: human|Concentration: As Reported|Form: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).|Purity: Purified by Protein A affinity chromatography.|Immunogen: NMDA Receptor 2B fusion protein.|Specificity: Recognizes the 160kD human NMDA receptor subunit 2B. |Species Crossreactivity: rat, canine and monkey||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
NMDA Receptor 2B fusion protein.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes the 160kD human NMDA receptor subunit 2B. |Species Crossreactivity: rat, canine and monkey
References
1. Varney, M.A., et al., Pharm. and Exp. Thera. 279: 367 (1996). 2. Sucher, N.J., et al., Trends Pharmacol. Sci. 17: 348–355 (1996).