PI 3 Kinase p85 alpha (PIK3R1) Mouse Monoclonal Antibody [Clone ID: AB6]
CAT#: AM26667AF-N
PI 3 Kinase p85 alpha (PIK3R1) mouse monoclonal antibody, clone AB6, Azide Free
Specifications
Product Data | |
Clone Name | AB6 |
Applications | IF, IP, WB |
Recommended Dilution | Western blot: 1 µg/mL for chemiluminescence detection system. Immunoprecipitation: 1-5 µg/600 µl of cell extract from 5x106 cells. Immunocytochemistry: 10 µg/ml. |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant human p85alpha. |
Specificity | This antibody reacts with p85alpha, which is regulatory subunit of PI3-kinase on Western blot, Immunoprecipitation and Immunocytochemistry. This |
Formulation | PBS containing 50% glycerol, pH 7.2 State: Azide Free State: Liquid Ig fraction without preservatives |
Concentration | lot specific |
Purification | Protein A agarose |
Conjugation | Unconjugated |
Storage | Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | phosphoinositide-3-kinase regulatory subunit 1 |
Database Link | |
Background | Phosphoinositide 3-kinase (PI3K) family of enzymes generate 3-phosphorylated phosphoinositides that act as second messengers downstream of numerous cellular receptors. This family control several cellular responses including cell growth, survival cytoskeletal remodeling and the trafficking of intracellular organelles in many different cell types. There are four subgroups (class IA, IB, II, III) of PI3K with distinct structure and substrate specificity. Class IA PI3K, which function downstream of activated tyrosine kinases, are heterodimers composed of a p110 catalytic subunit (a, b, or o) and a tightly associated regulatory subunit (p85a, p55a, p50a, p85B, or p55y). Each regulatory subunit can interchangeably associate with different catalytic subunits and shows a unique tissue distribution. p85a is the major regulatory subunit of class IA PI3Ks in most types of cells including immune cells. |
Synonyms | PI3K regulatory subunit alpha, PI3-kinase subunit p85-alpha |
Note | This product was originally produced by MBL International. |
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